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Published on: February 1, 2012
Sympathetic skin response (SSR) in Crohn disease: a pilot study.
A R Ashraf1, A R Taghavi, A R Moghtaderi
1Shiraz University of Medial Sciences, Shiraz, Iran.
Electromyography and Clinical Neurophysiology
|March 31, 2010
Summary
Crohn disease patients may have sub-clinical sympathetic nervous system dysfunction. Sympathetic skin response (SSR) testing can detect early autonomic changes in peripheral neuropathy associated with Crohn disease.
Area of Science:
- Neurology
- Gastroenterology
- Autonomic Neuroscience
Background:
- Peripheral neuropathy is a common neurological complication in Crohn disease (CD).
- Previous research indicated sympathetic neuropathy as an early sign of CD using physical tests.
Purpose of the Study:
- To investigate sympathetic neuropathy in CD patients using sympathetic skin response (SSR).
Main Methods:
- SSR was performed on 6 patients diagnosed with CD (4 male, 2 female; age 26-68).
- Patients had a disease duration of at least 4 years and no overt autonomic dysfunction symptoms.
- Hand and foot latencies were measured and compared to control groups.
Main Results:
- CD patients exhibited prolonged hand and foot latencies compared to controls.
- The difference in hand latencies was statistically significant.
- Two patients showed completely abnormal SSR results.
Conclusions:
- Sub-clinical sympathetic dysfunction is present in Crohn disease patients.
- SSR testing is a valuable tool for identifying early autonomic changes in CD-associated peripheral neuropathy.
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