Mango extracts and the mango component mangiferin promote endothelial cell migration
Noor Huda Daud1, Cho Sanda Aung, Amitha K Hewavitharana
1School of Pharmacy, University of Queensland, Woolloongabba, Queensland, Australia.
Journal of Agricultural and Food Chemistry
|March 31, 2010
Summary
Mango extracts, particularly mangiferin, promote endothelial cell migration, crucial for new blood vessel formation. This suggests potential therapeutic benefits for conditions involving impaired angiogenesis.
Area of Science:
- Biochemistry
- Cell Biology
- Pharmacology
Background:
- Endothelial cell migration is vital for angiogenesis, the formation of new blood vessels.
- Angiogenesis is a key therapeutic target for conditions like limb ischemia, coronary infarction, and stroke.
- Mango extracts contain bioactive polyphenolic compounds with potential health benefits.
Purpose of the Study:
- To investigate the effect of mango extracts and specific polyphenols (mangiferin, quercetin) on endothelial cell migration.
- To determine if mangiferin or mango extracts can modulate angiogenesis-related processes.
- To explore the potential health-promoting effects of mango components in vascular diseases.
Main Methods:
- Utilized a modified Boyden chamber assay to assess bovine aortic endothelial cell migration.
- Tested the effects of mango peel and flesh extracts.
- Evaluated the impact of isolated mangiferin and quercetin on cell migration and proliferation.
Main Results:
- Mangiferin and mangiferin-rich mango extracts significantly increased endothelial cell migration.
- The promigratory effect was dose-dependent and potentially modulated by other extract components.
- This effect was independent of changes in cell proliferation or matrix metalloproteinase (MMP-2, MMP-9) production.
Conclusions:
- Mangiferin, a key component in mango extracts, promotes endothelial cell migration.
- Mango extracts may offer health benefits for diseases characterized by impaired angiogenesis.
- Further research into mangiferin's therapeutic potential in vascular conditions is warranted.
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