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Updated: Jun 14, 2026

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Prostate biopsy in Western Australia 1998-2004.

B A O'Brien¹, A L Brown, T Shannon

¹Tissugen Pty Ltd, Perth, Western Australia.

Prostate Cancer and Prostatic Diseases

|March 31, 2010

Summary

This summary is machine-generated.

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Prostate cancer diagnosis in Western Australia showed higher detection rates and higher-grade tumors compared to US screening trials. This suggests potentially more conservative urological practices led to underdiagnosis.

Area of Science:

Urology
Oncology
Pathology

Background:

Prostate cancer diagnosis relies on PSA testing and biopsy.
Variations in diagnostic practices can impact cancer detection rates.
Understanding regional differences in urological practice is crucial for accurate diagnosis.

Purpose of the Study:

To review prostate cancer diagnosis in Western Australia (WA) from 1998-2004.
To compare WA diagnostic rates with US screening data (Prostate, Lung, Colorectal and Ovarian - PLCO).
To inform decision-making regarding PSA testing and prostate biopsy.

Main Methods:

Retrospective review of 5145 men undergoing initial prostate biopsy in WA.
Analysis of cancer detection rates and histological grade (Gleason sum).

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Last Updated: Jun 14, 2026

Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance

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Published on: June 6, 2025

Use of Magnetic Resonance Imaging and Biopsy Data to Guide Sampling Procedures for Prostate Cancer Biobanking

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Published on: October 10, 2019

Comparison of WA data with baseline data from the US PLCO cancer screening trial.

Main Results:

Cancer detection rates were 59% for initial and 32% for repeat biopsies.
High-grade cancer (Gleason sum ≥7) was detected in 69% of initial and 38% of repeat biopsies.
WA diagnosis rates and high-grade tumor detection were 1.6-fold higher than in the US PLCO trial.

Conclusions:

Urological practice in WA (1998-2004) was more conservative than in the US, potentially leading to prostate cancer underdiagnosis.
Higher detection rates and histological grade suggest a more cautious diagnostic approach.
Findings may be relevant for countries with differing urological practices compared to the US.