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Updated: Jan 4, 2026

A Method for Murine Islet Isolation and Subcapsular Kidney Transplantation
Published on: April 13, 2011
β-Cell and renal transplantation options for diabetes
A J S Flatt1,2, D Bennett2, C Counter3
1Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
Abstract:
Despite major advances in structured education, insulin delivery and glucose monitoring, diabetes self-management remains an unremitting challenge. Insulin therapy is inextricably linked to risk of dangerous hypoglycaemia and sustained hyperglycaemia remains a leading cause of renal failure. This review sets out to demystify transplantation for diabetes multidisciplinary teams, facilitating consideration and incorporation within holistic overall person-centred management. Deceased and living donor kidney, whole pancreas and isolated islet transplant procedures, indications and potential benefits are described, in addition to outcomes within the integrated UK transplant programme.
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