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A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
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A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

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Carotid intima-media thickness in patients with end-stage renal disease

K Sunil Kumar1, A Y Lakshmi, P V L N Srinivasa Rao

  • 1Department of Nephrology, Sri Venkateswara Institute of Medical Sciences, Tirupati, India.

Indian Journal of Nephrology
|March 31, 2010
PubMed

Insights

Patients with end-stage renal disease (ESRD) show higher carotid intima-media thickness (CIMT), a marker of atherosclerosis, and increased oxidative stress. This noninvasive measurement is valuable for assessing cardiovascular risk in chronic kidney disease patients.

Area of Science:

  • Nephrology
  • Cardiology
  • Vascular Biology

Background:

  • Accelerated atherosclerosis and cardiovascular disease are leading causes of death in end-stage renal disease (ESRD) patients.
  • Carotid intima-media thickness (CIMT) serves as a reliable indicator of atherosclerosis.
  • Oxidative stress is implicated in the pathogenesis of cardiovascular complications in ESRD.

Purpose of the Study:

  • To investigate carotid intima-media thickness (CIMT) in end-stage renal disease (ESRD) patients before dialysis initiation.
  • To assess the relationship between CIMT and markers of oxidative stress in ESRD.
  • To evaluate CIMT as a diagnostic tool for atherosclerosis in chronic kidney disease.

Main Methods:

  • Ultrasonography was used to measure CIMT in 30 ESRD patients prior to dialysis.
  • Serum oxidative stress markers were quantified in ESRD patients and compared to controls.
  • CIMT measurements were compared between ESRD patients and a control group.

Main Results:

  • ESRD patients exhibited significantly higher CIMT compared to the control group.
  • Elevated levels of serum oxidative stress markers were observed in ESRD patients.
  • A correlation between increased CIMT and heightened oxidative stress was suggested.

Conclusions:

  • CIMT is elevated in ESRD patients, indicating accelerated atherosclerosis.
  • Increased oxidative stress is present in ESRD patients.
  • CIMT is a practical, noninvasive, and cost-effective method for evaluating atherosclerosis in chronic renal failure.

Keywords:
Carotid intima-media thicknessatherosclerosisend-stage renal disease

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