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Updated: Jun 14, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Pathophysiology of migraine.

F Michael Cutrer¹

¹Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA. Cutrer.michael@mayo.edu

Seminars in Neurology

|March 31, 2010

Summary

Migraine

Area of Science:

Neurology
Neuroscience

Background:

Migraine pathophysiology is complex and not fully understood.
Traditional theories are being updated with new research.
Genetics plays a significant role in migraine development.

Purpose of the Study:

To summarize current knowledge on migraine pathophysiology.
To review migraine genetics, neuroimaging, and neurophysiology.
To highlight the complexity of migraine as a disorder.

Main Methods:

Review of existing literature on migraine.
Focus on neuroanatomy and pain physiology.
Analysis of recent genetic, neuroimaging, and neurophysiological data.

Main Results:

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Last Updated: Jun 14, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Ex Vivo Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents

Ex Vivo Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents

Published on: May 16, 2022

Migraine likely results from multiple initiating abnormalities, not a single cause.
Genetics is increasingly recognized as a key factor.
Neuroimaging and neurophysiology provide insights into migraine mechanisms.

Conclusions:

A single unifying explanation for migraine is unlikely.
Migraine attacks may be the final common pathway for diverse underlying issues.
Further research into migraine genetics and neurobiology is crucial.