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Published on: May 20, 2018
[Development of a novel liquid injection system]
1School of Mechanical Engineering, Hangzhou Dianzi University, Hangzhou Zhejiang, China.
Summary
A novel domestic liquid jet injector was designed to deliver drugs through the skin. Testing confirmed its high-velocity stream, exceeding the 15 MPa threshold for effective skin penetration.
Area of Science:
- Biomedical Engineering
- Drug Delivery Systems
- Medical Device Design
Context:
- Liquid jet injectors utilize compressed gas or springs for high-velocity drug delivery through the skin.
- Existing clinical jet injection products are not domestically produced.
- A comprehensive analysis of current products informed the design of a new injector.
Purpose:
- To design and develop a novel domestic liquid jet injector.
- To analyze and characterize the jetting performance of the new device.
Summary:
- A new liquid jet injector was designed, incorporating an ejector, trigger, and re-positioning mechanism.
- Performance testing demonstrated a maximum exit pressure exceeding 15 MPa, a critical threshold for skin penetration.
- This indicates the device's capability for effective transdermal drug delivery.
Impact:
- Provides a domestic alternative to existing imported liquid jet injection technologies.
- Potential to improve patient compliance and accessibility for transdermal drug therapies.
- Establishes a foundation for further development and clinical application of indigenous jet injection systems.
