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Updated: Jun 14, 2026

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way
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Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way

Published on: May 10, 2021

Dermatofibrosarcoma protuberans: how wide should we resect?

Jeffrey M Farma1, John B Ammori, Jonathan S Zager

  • 1Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA. Jeffrey.Farma@fccc.edu

Annals of Surgical Oncology
|April 1, 2010
PubMed
Summary
This summary is machine-generated.

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Dermatofibrosarcoma protuberans (DFSP) treatment using wide excision (WE) with margin evaluation achieved a 1% local recurrence rate. This approach, with a median 2 cm margin, is effective for DFSP on the trunk and extremities.

Area of Science:

  • Oncology
  • Dermatology
  • Surgical Pathology

Background:

  • Dermatofibrosarcoma protuberans (DFSP) is a rare skin tumor with variable local recurrence rates (0-50%).
  • Surgical management of DFSP remains controversial, with debates on optimal margin width and excision techniques (Mohs surgery vs. wide excision).

Purpose of the Study:

  • To evaluate the efficacy of wide excision (WE) with total peripheral margin pathologic evaluation for Dermatofibrosarcoma protuberans (DFSP).
  • To assess recurrence rates, margin status, and patient outcomes following standardized WE for DFSP.

Main Methods:

  • Retrospective review of 206 DFSP lesions in 204 patients treated with WE (1-2 cm margins) between 1991-2008.
  • Pathologic analysis included en face sectioning for margin evaluation; further excision was performed for positive margins.

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A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies
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Last Updated: Jun 14, 2026

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  • Data collected on margin width, number of excisions, reconstruction methods, radiation use, and patient outcomes.

    • Main Results:

    • A median of 1 excision with a median width of 2 cm achieved negative margins in most cases.
    • Primary closure was feasible in 69% of patients; 1% experienced local recurrence at a median follow-up of 64 months.
    • Postoperative radiation was administered to 9 patients, primarily for positive margins after maximal surgical excision.

    Conclusions:

    • Standardized wide excision (WE) with meticulous margin evaluation yields a very low local recurrence rate (1%) for DFSP.
    • A median margin of 2 cm is effective, facilitating primary closure in most cases and reducing morbidity.
    • This approach is recommended as the treatment of choice for DFSP on the trunk and extremities.