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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Degenerative Disc Disease ll: Pathophysiology01:23

Degenerative Disc Disease ll: Pathophysiology

The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Degenerative Disc Disease I: Introduction01:27

Degenerative Disc Disease I: Introduction

Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...

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Related Experiment Video

Updated: Jun 14, 2026

Erosion Identification in Metacarpophalangeal Joints in Rheumatoid Arthritis using High-Resolution Peripheral Quantitative Computed Tomography
06:31

Erosion Identification in Metacarpophalangeal Joints in Rheumatoid Arthritis using High-Resolution Peripheral Quantitative Computed Tomography

Published on: October 6, 2023

A geriatric patient with diffuse idiopathic skeletal hyperostosis.

Berrin Karadag1, Huseyin Cat, Selma Aksoy

  • 1Sisli Etfal Research and Training Hospital, 2. Internal Medicine Clinic, Sisli, 34377, Istanbul, Turkey. bekaradag@yahoo.com

World Journal of Gastroenterology
|April 1, 2010
PubMed
Summary

Diffuse idiopathic skeletal hyperostosis (Forestier's disease) can cause severe dysphagia in elderly patients. This case highlights the importance of considering skeletal abnormalities in the diagnosis of swallowing difficulties.

Related Experiment Videos

Last Updated: Jun 14, 2026

Erosion Identification in Metacarpophalangeal Joints in Rheumatoid Arthritis using High-Resolution Peripheral Quantitative Computed Tomography
06:31

Erosion Identification in Metacarpophalangeal Joints in Rheumatoid Arthritis using High-Resolution Peripheral Quantitative Computed Tomography

Published on: October 6, 2023

Area of Science:

  • Geriatrics
  • Gastroenterology
  • Radiology

Background:

  • Chronic and degenerative diseases are common in senility.
  • Elderly patients often present with complex health issues requiring thorough diagnostic evaluation.

Observation:

  • A 75-year-old male nursing home resident presented with significant weight loss and dysphagia.
  • Gastrointestinal endoscopy revealed a hypopharyngeal and esophageal mass obstructing the lumen.
  • CT scan showed narrowing due to osseous hypertrophy in the hypopharynx and proximal esophagus.

Findings:

  • The patient's symptoms were attributed to Diffuse Idiopathic Skeletal Hyperostosis (Forestier's disease).
  • This condition involves ossification of spinal ligaments, leading to esophageal compression.
  • The diagnostic process involved endoscopy and CT imaging to identify the cause of dysphagia.

Implications:

  • Forestier's disease should be considered in the differential diagnosis of dysphagia and weight loss in the elderly.
  • Early and accurate diagnosis is crucial for managing nutritional deficits and improving patient outcomes.
  • This case underscores the need for a multidisciplinary approach in geriatric care, integrating imaging and endoscopic findings.