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Silicon Nanowires and Optical Stimulation for Investigations of Intra- and Intercellular Electrical Coupling

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Published on: January 28, 2021

What the cell "sees" in bionanoscience.

Dorota Walczyk¹, Francesca Baldelli Bombelli, Marco P Monopoli

¹Centre for BioNano Interactions, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland.

Journal of the American Chemical Society

|April 2, 2010

Summary

Nanoparticles interacting with biological systems are covered by biomolecular "coronas." These protein layers, rather than the bare nanoparticle, are what cells detect, persisting long enough to influence biological interactions.

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Area of Science:

Nanomedicine
Biomaterials Science
Cellular Biology

Background:

Nanoparticles interact with biological systems through a layer of adsorbed biomolecules, termed a "corona."
The composition and stability of this corona significantly influence nanoparticle biological identity and interactions.
Understanding corona dynamics is crucial for predicting nanoparticle behavior in vivo.

Purpose of the Study:

To investigate the stability and characteristics of biomolecular coronas formed on nanoparticles in biological media.
To determine if these coronas persist long enough to be the primary determinant of cellular interaction.
To assess the feasibility of isolating and studying these coronas independently.

Main Methods:

Time-resolved analysis of biomolecular corona formation and stability.
In situ and isolated studies of nanoparticle-biomolecule complexes.
Utilized multiple methodologies to characterize corona structure and lifetime.

Main Results:

Biomolecular coronas, particularly those derived from blood plasma, are sufficiently stable and long-lived.
These stable coronas can be physically isolated without structural alteration.
The corona, not the bare nanoparticle surface, is likely recognized by biological cells.

Conclusions:

The biomolecular corona dictates cellular interactions with nanoparticles, not the intrinsic material properties.
Current methods classifying nanomaterials based on bare properties may be insufficient.
The reported methodologies offer a pathway to better understand and predict nanomaterial biological impacts for safety and fundamental science.