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Updated: Jun 14, 2026

Imaging Metals in Brain Tissue by Laser Ablation - Inductively Coupled Plasma - Mass Spectrometry (LA-ICP-MS)
Published on: January 22, 2017
Collision/reaction cell ICP-MS with shielded torch and sector field ICP-MS for the simultaneous determination of
Khalid A Al-Saad1, Mohammed A Amr, Abdulfattah I Helal
1Central Laboratories Unit, Qatar University, Doha, Qatar.
Abstract:
The determinations of selenium isotopes in biological samples were performed using both inductively coupled plasma collision/reaction cell quadruple mass spectrometer (CRC-ICP-QMS) and inductively coupled plasma sector field mass spectrometers (SF-ICP-MS). To significantly decrease the argon-based interferences at m/z 74 ((36)Ar(38)Ar), 76 ((38)Ar(38)Ar, (40)Ar(36)Ar), 78 ((38)Ar(40)Ar), and 80 ((40)Ar(40)Ar), the gas-flow rates of a helium and hydrogen mixture used in the collision cell were optimized to 1.0 mL/min H(2) and 3.5 mL/min He. Under the optimized condition, the precisions for natural selenium isotope ratio measurements of both instruments were evaluated and compared using 100 ppb Se standard solution. A modified external calibration quantification method was applied for the simultaneous determination of clinically used enriched selinocompounds ((77)Se-selenate, (82)Se-selenite, (76)Se-methylseleninic acid(IV), (78)Se-methylselenonic acid(VI)) and to examine their fate in rat organs (liver, kidney, and lung).
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