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Lymphoid Cells and Tissues

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Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...

Functions of the Lymphatic and Immune System

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The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
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Introduction to Lymphatic and Immune System

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Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
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Loose Connective Tissue

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Secondary Lymphoid Organs

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Related Experiment Video

Updated: Jun 14, 2026

Identification and Dissection of Diverse Mouse Adipose Depots

Identification and Dissection of Diverse Mouse Adipose Depots

Published on: July 11, 2019

Adipose tissue lymphocytes: types and roles.

S Caspar-Bauguil¹, B Cousin, S Bour

¹UPS, UMR 5241, Métabolisme, Plasticité et Mitochondrie, Université de Toulouse III, Toulouse, USA. casparbauguil.s@chu-toulouse.fr

Journal of Physiology and Biochemistry

|April 2, 2010

Summary

This summary is machine-generated.

White adipose tissue (WAT) contains various lymphocytes that change in obesity. These immune cells may influence fat tissue and offer potential for treating metabolic disorders.

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Localization, Identification, and Excision of Murine Adipose Depots

Localization, Identification, and Excision of Murine Adipose Depots

Published on: December 4, 2014

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Last Updated: Jun 14, 2026

Identification and Dissection of Diverse Mouse Adipose Depots

Identification and Dissection of Diverse Mouse Adipose Depots

Published on: July 11, 2019

Localization, Identification, and Excision of Murine Adipose Depots

Localization, Identification, and Excision of Murine Adipose Depots

Published on: December 4, 2014

Area of Science:

Immunology
Endocrinology
Metabolic research

Background:

White adipose tissue (WAT) comprises adipocytes and other cells, including a significant proportion of lymphocytes.
Lymphocyte populations (B, T, NK, NKT) in WAT vary by anatomical location, with visceral fat linked to innate immunity and subcutaneous fat to adaptive immunity in mice.
Lymphocyte numbers and activity, excluding B cells, are altered in obesity, influenced by obesity severity, leptin levels, and fat depot location.

Purpose of the Study:

To investigate the role and alterations of lymphocytes within white adipose tissue, particularly in the context of obesity.
To explore the intricate crosstalk between immune cells and fat cells in WAT.
To evaluate the potential of immunotherapy for treating obesity-related metabolic disorders.

Main Methods:

Detection and characterization of various lymphocyte types (B, alphabetaT, gammadeltaT, NK, NKT) in rodent and human WAT.
Analysis of lymphocyte proportions and activity in relation to obesity, leptin concentration, and fat depot location.
Review of existing evidence on lymphocyte-adipokine receptor interactions and chemokine production in WAT.

Main Results:

Lymphocyte composition and number are modified in obesity, with alterations preceding macrophage infiltration and WAT inflammation.
Lymphocyte populations in WAT exhibit distinct immune roles based on anatomical location (visceral vs. subcutaneous).
Evidence suggests lymphocytes regulate adipocyte and other immune cell numbers and functions within WAT.

Conclusions:

Lymphocytes play a crucial role in regulating WAT cellularity and metabolic/secretory activities.
Alterations in lymphocyte populations are early events in obesity-related WAT dysfunction.
Immunotherapy presents a promising avenue for managing endocrinometabolic disorders associated with excessive fat mass.