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Related Experiment Videos

Current status of mold immunotherapy.

M Dhillon1

  • 1Queen's University Kingston, Ontario, Canada.

Annals of Allergy
|May 1, 1991
PubMed
Summary

Molds can trigger allergic upper respiratory issues, with immunotherapy showing promise. However, standardized mold extracts are crucial for accurate diagnosis and effective treatment, as current commercial options are unreliable.

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Area of Science:

  • Allergy and Immunology
  • Environmental Health
  • Respiratory Medicine

Background:

  • Molds are implicated in IgE-mediated upper respiratory tract disorders.
  • Specific mold families like Cladosporium, Basidiospores, Aspergillus, and Alternaria-Penicillin dominate environmental mold load.
  • The role of absolute mold levels in IgE formation and symptom induction remains uncertain.

Purpose of the Study:

  • To evaluate the efficacy of mold immunotherapy.
  • To address the limitations of current mold extracts used in diagnosis and treatment.
  • To highlight the need for standardized mold reagents.

Main Methods:

  • Review of environmental sampling studies identifying dominant mold species.
  • Analysis of existing clinical trials on mold immunotherapy.
  • Assessment of the standardization and reliability of commercial mold extracts for skin testing and immunotherapy.

Main Results:

  • Standardized Cladosporium extract has shown efficacy in immunotherapy trials.
  • Commercial mold extracts in the US are highly variable, leading to false negatives in skin testing.
  • Current mold extracts are considered poor reagents for both skin testing and immunotherapy.

Conclusions:

  • Standardized mold extracts are essential for accurate diagnosis and effective immunotherapy.
  • The efficacy of Cladosporium immunotherapy cannot be generalized to variable commercial extracts.
  • Urgent development of standardized mold reagents is needed to advance mold allergy research and treatment.

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