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Murine Isolated Heart Model of Myocardial Stunning Associated with Cardioplegic Arrest
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Stunned and hibernating myocardium

R A Kloner1, K Przyklenk

  • 1Heart Institute, Hospital of the Good Samaritan, Los Angeles, California 90017.

Annual Review of Medicine
|January 1, 1991
PubMed

Insights

Non-functioning myocardium can be dead, stunned, hibernating, or ischemic. Studies confirm stunned myocardium in humans and hibernating myocardium in patients with chronic low flow ischemia, showing improved function after revascularization.

Area of Science:

  • Cardiology
  • Physiology

Background:

  • Non-functioning myocardium presents diagnostic challenges.
  • Potential states include infarction, stunning, hibernation, or acute ischemia.

Purpose of the Study:

  • To review the evidence for stunned and hibernating myocardium.
  • To differentiate these states from irreversible myocardial damage.

Main Methods:

  • Review of experimental and clinical studies.
  • Analysis of data from coronary artery occlusion/reperfusion models.
  • Evaluation of clinical outcomes following revascularization in ischemic heart disease.

Main Results:

  • Stunned myocardium (postischemic ventricular dysfunction) is well-documented experimentally and clinically.
  • Hibernating myocardium (viable tissue in chronic low flow) is supported by clinical evidence.
  • Revascularization improves left ventricular function in hibernating myocardium.

Conclusions:

  • Stunned and hibernating myocardium represent distinct states of viable but dysfunctional heart muscle.
  • These findings have implications for diagnosing and treating ischemic heart disease.
  • Understanding these myocardial states is crucial for guiding therapeutic interventions.

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