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Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
Published on: May 26, 2022
Hydrogen sulfide inhibits plasma renin activity
Ming Lu1, Yi-Hong Liu, Hong Swen Goh
1Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117456.
Journal of the American Society of Nephrology : JASN
|April 3, 2010
Summary
Hydrogen sulfide (H2S) can prevent and treat renovascular hypertension by inhibiting renin release. This finding suggests H2S as a potential therapeutic for hypertension.
Area of Science:
- Biochemistry
- Physiology
- Pharmacology
Background:
- Renovascular hypertension development is linked to renin release from juxtaglomerular (JG) cells, regulated by intracellular cyclic adenosine monophosphate (cAMP).
- Hydrogen sulfide (H2S) inhibits adenylyl cyclase, reducing cAMP production in certain cells, indicating a potential role in modulating renin release.
Purpose of the Study:
- To investigate the effects of H2S on plasma renin activity and blood pressure (BP) in rat models of renovascular hypertension.
- To explore the therapeutic potential of H2S in managing renovascular hypertension.
Main Methods:
- Utilized the two-kidney-one-clip (2K1C) rat model to induce renovascular hypertension.
- Administered the H2S donor, sodium hydrosulfide (NaHS), to assess its impact on BP, plasma renin activity, angiotensin II, and renin mRNA/protein levels.
- Examined the effect of NaHS on renin release and cAMP levels in primary kidney cell cultures.
Main Results:
- NaHS administration prevented and treated hypertension in 2K1C rats.
- NaHS significantly reduced elevated plasma renin activity and angiotensin II levels in 2K1C rats.
- NaHS suppressed renin mRNA and protein upregulation in clipped kidneys and inhibited forskolin-stimulated renin release and cAMP increase in kidney cells.
Conclusions:
- Hydrogen sulfide inhibits renin activity by decreasing renin synthesis and release.
- H2S demonstrates potential as a therapeutic agent for renovascular hypertension.
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