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Related Concept Videos

Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

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Related Experiment Video

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Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
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[New ophthalmic insert].

Mihaela Hamcerencu1, Marcel Popa, Danut Costin

  • 1"Gh. Asachi" Technical University, Faculty of Chemical Engineering, Department of Natural and Synthetic Polymers, Bd. D. Mangeron, nr. 71 A, 700050 Iasi, Romania.

Oftalmologia (Bucharest, Romania : 1990)
|April 6, 2010
PubMed
Summary
This summary is machine-generated.

This study developed a smart hydrogel for controlled ophthalmic drug delivery. The thermosensitive hydrogel releases medication at physiological temperatures, offering effective and well-tolerated ocular treatment.

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Area of Science:

  • Ophthalmology
  • Materials Science
  • Pharmacology

Background:

  • Controlled drug release is crucial for modern ophthalmic pharmacology.
  • Ophthalmic products with prolonged and targeted action are a key research area.
  • Hydrogels are significant materials for developing advanced drug delivery systems.

Purpose of the Study:

  • To evaluate a monolithic thermosensitive hydrogel for controlled release of ophthalmic drugs.
  • To assess the potential of hydrogels in creating sustained-action ophthalmic formulations.
  • To investigate the feasibility of thermosensitive hydrogels for targeted drug delivery in the eye.

Main Methods:

  • Hydrogel synthesis and characterization.
  • In vitro drug release kinetics studies.
  • In vivo tolerability and efficacy assessments in ocular models.

Main Results:

  • MA-G and PNIPAm-based hydrogels demonstrated thermosensitive properties, collapsing near physiological temperatures.
  • This collapse facilitated controlled drug release in desired doses.
  • The developed hydrogel exhibited excellent ocular tolerability in experimental studies.

Conclusions:

  • Thermosensitive hydrogels enable controlled release of active drugs at small, effective doses.
  • This approach minimizes adverse effects, achieving targeted drug delivery.
  • The hydrogel system is a promising platform for advanced ophthalmic therapeutics.