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A new triterpene glycoside from Centella erecta
Chidananda S Rumalla1, Zulfiqar Ali, Aruna D Weerasooriya
1National Center for Natural Products Research, School of Pharmacy, University of Mississippi, MS 38677, USA.
Fitoterapia
|April 6, 2010
Summary
A novel ursane-type triterpenoid saponin was identified from Centella erecta. This new compound, along with eighteen known natural products, expands our understanding of the plant's chemical constituents.
Area of Science:
- Phytochemistry
- Natural Products Chemistry
- Pharmacognosy
Background:
- Centella erecta (L.f.) Fern. is a plant species known for its diverse secondary metabolites.
- Ethnobotanical uses suggest potential for bioactive compounds within this species.
- Previous phytochemical investigations have identified various triterpenoids and saponins.
Purpose of the Study:
- To isolate and characterize novel and known compounds from Centella erecta.
- To elucidate the chemical structure of a new ursane-type triterpenoid saponin.
- To contribute to the phytochemical knowledge of the Centella genus.
Main Methods:
- Extraction and isolation of compounds using chromatographic techniques.
- Structure elucidation utilizing Nuclear Magnetic Resonance (NMR) spectroscopy.
- High-Resolution Electrospray Ionization Mass Spectrometry (HRESIMS) for molecular formula determination.
- Comparison of spectral data with existing literature for known compounds.
Main Results:
- Isolation of a new ursane-type triterpenoid saponin: (2α,3β)-23-sulphonyl-2,3-dihydroxyurs-12-en-28-oic acid O-α-L-rhamnopyranosyl-(1 → 4)-O-β-D-glucopyranosyl-(1 → 6)-O-β-D-glucopyranosyl ester (1).
- Identification of eighteen known compounds from the same plant extract.
- Comprehensive structural characterization of all isolated compounds.
Conclusions:
- The phytochemical investigation of Centella erecta led to the discovery of a new triterpenoid saponin.
- The study expands the repertoire of known natural products from this species.
- The findings provide a basis for further research into the biological activities of these compounds.
