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Updated: Jun 14, 2026

Optimization of Breast Biopsy and Mastectomy Sample Collection Procedures for Biobanking, Personalized Medicine, and Research Applications
Published on: September 2, 2025
Optimization of clinical breast examination
William H Goodson1, Thomas K Hunt, Julia N Plotnik
1Department of Surgery, California Pacific Medical Center Research Institute, San Francisco, CA, USA. goodsow@cpmcri.org
Focusing clinician attention on breast examination results with a dedicated form doubled the rate of further patient evaluation. This simple intervention improved breast cancer detection without retraining examination techniques.
Area of Science:
- Oncology
- Medical Quality Improvement
- Clinical Practice
Background:
- Mammograms miss 8-17% of breast cancers, necessitating clinical breast examination.
- Breast examinations are performed less frequently and effectively.
- Improving breast examination quality is crucial for early cancer detection.
Purpose of the Study:
- To determine if focusing clinician attention can improve breast examination quality.
- To assess the impact of dedicated forms on the call rate without retraining.
Main Methods:
- Clinicians were randomized to use either a long or short dedicated form after routine breast examinations.
- No retraining in breast examination techniques was provided.
- Call rates from the study were compared to historical controls.
Main Results:
- The call rate significantly increased from 4.7% to 8.3% when dedicated forms were used.
- This improvement suggests a Hawthorne effect, where the act of data collection influenced outcomes.
- Four cancers were detected in 1822 patients, aligning with predictions.
Conclusions:
- Using a dedicated form to focus attention on breast examination findings doubled the call rate.
- Clinician attention, not technique retraining, improved breast examination quality.
- This method enhances the effectiveness of clinical breast examinations.
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