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Published on: July 15, 2019
A biophysical model for cardiac microimpedance measurements
Andrew E Pollard1, Roger C Barr
1Cardiac Rhythm Management Laboratory, Univ. of Alabama at Birmingham, Volker Hall B140, 1670 Univ. Blvd., Birmingham, AL 35294. apollard@uab.edu
Summary
This study introduces a novel method for in vivo measurement of cardiac tissue electrical conductance at the microscopic level. The technique utilizes multisite stimulation and biophysical modeling to accurately assess tissue properties and aid in understanding arrhythmia development.
Area of Science:
- Biophysics
- Cardiac Electrophysiology
- Biomedical Engineering
Background:
- Arrhythmia development is linked to altered cardiac tissue electrical conductance and collagen structure.
- Current methods lack in vivo measurement capabilities at the microscopic scale.
Purpose of the Study:
- To present and validate a novel method for direct in vivo measurement of microscopic cardiac tissue electrical conductance.
- To investigate the comprehensive performance of this method using biophysical modeling.
Main Methods:
- Interstitial multisite stimulation at subcellular to cellular scales.
- Utilizing a 3D structural framework coupling interstitial, intracellular, and membrane components.
- Employing electrodes with small separations for precise measurements.
Main Results:
- The method successfully measures passive tissue resistances in all geometric dimensions.
- Multi-frequency and multi-electrode separation measurements provide robust predictions.
- Distinguishing between interstitial and intracellular compartment contributions is readily achieved due to small electrode size.
Conclusions:
- The developed method enables direct in vivo measurement of microscopic cardiac electrical conductance.
- This technique offers a powerful tool for understanding tissue properties relevant to arrhythmia.
- The biophysical modeling validates the comprehensive performance of the proposed measurement plan.
