Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cleavage and Blastulation

Cleavage and Blastulation

After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Human stem cell-based embryo models: innovation, ethics, and policy.

Human reproduction (Oxford, England)·2026

Same author

Enhancing rigor and reproducibility: Implementing STAR Methods and the ISSCR Standards Checklist at Stem Cell Reports.

Stem cell reports·2026

Same author

Author Correction: Tissue-scale coordination of cellular behaviour promotes epidermal wound repair in live mice.

Nature cell biology·2025

Same author

Stem cell-based embryo models: The 2021 ISSCR stem cell guidelines revisited.

Stem cell reports·2025

Same author

Author Correction: A comprehensive human embryo reference tool using single-cell RNA-sequencing data.

Nature methods·2025

Same author

Editorial.

Stem cell reports·2025

Same journal

Julie Zikherman receives the ASCI/Marian W. Ropes, MD, Award.

The Journal of clinical investigation·2026

Same journal

Targeted degradation of MDM2 overcomes feedback regulation of p53 signaling in Merkel cell carcinoma models.

The Journal of clinical investigation·2026

Same journal

SGLT2 inhibitors enhance ketogenesis by acting as allosteric activators of the mitochondrial enzyme HMGCS2.

The Journal of clinical investigation·2026

Same journal

MDM2 degraders for Merkel cell carcinoma: round peg in a round hole.

The Journal of clinical investigation·2026

Same journal

Ammonia in the crosshairs: microbial targets for metabolic dysfunction-associated steatohepatitis prevention.

The Journal of clinical investigation·2026

Same journal

Molecular mechanisms regulating cGAS/STING activation in health and disease.

The Journal of clinical investigation·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 6, 2026

Derivation of Mouse Trophoblast Stem Cells from Blastocysts

Derivation of Mouse Trophoblast Stem Cells from Blastocysts

Published on: June 9, 2010

Making the blastocyst: lessons from the mouse.

Katie Cockburn¹, Janet Rossant

¹Department of Molecular Genetics, University of Toronto, Canada.

The Journal of Clinical Investigation

|April 6, 2010

Summary

This summary is machine-generated.

Mammalian preimplantation development forms a blastocyst with three lineages. Comparing human and mouse development is crucial for reproductive technologies and stem cell research.

More Related Videos

Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos

Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos

Published on: February 22, 2016

Loss- and Gain-of-function Approach to Investigate Early Cell Fate Determinants in Preimplantation Mouse Embryos

Loss- and Gain-of-function Approach to Investigate Early Cell Fate Determinants in Preimplantation Mouse Embryos

Published on: June 6, 2016

Related Experiment Videos

Last Updated: May 6, 2026

Derivation of Mouse Trophoblast Stem Cells from Blastocysts

Derivation of Mouse Trophoblast Stem Cells from Blastocysts

Published on: June 9, 2010

Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos

Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos

Published on: February 22, 2016

Loss- and Gain-of-function Approach to Investigate Early Cell Fate Determinants in Preimplantation Mouse Embryos

Loss- and Gain-of-function Approach to Investigate Early Cell Fate Determinants in Preimplantation Mouse Embryos

Published on: June 6, 2016

Area of Science:

Developmental biology
Cell lineage specification
Comparative embryology

Background:

Mammalian preimplantation development spans fertilization to implantation, forming a blastocyst with epiblast, trophectoderm, and primitive endoderm.
The epiblast forms the embryo, while trophectoderm and primitive endoderm become extra-embryonic tissues.
Mouse preimplantation development is well-studied, but human development parallels are less clear.

Purpose of the Study:

To compare mouse and human preimplantation development.
To understand the establishment of blastocyst lineages in both species.
To identify similarities and differences between human and mouse early development.

Main Methods:

Comparative analysis of developmental events.
Review of recent discoveries in blastocyst lineage establishment.
Literature synthesis on mouse and human preimplantation development.

Main Results:

Significant progress in understanding mouse preimplantation development.
Identification of key events in blastocyst lineage formation.
Highlighting the need for further research into human preimplantation development.

Conclusions:

Understanding human preimplantation development is essential.
Comparative studies inform assisted reproductive technologies.
Knowledge gained aids in deriving human embryonic stem cells.