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Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
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Phase Contrast and Differential Interference Contrast Microscopy

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Doppler Optical Coherence Tomography of Retinal Circulation
10:46

Doppler Optical Coherence Tomography of Retinal Circulation

Published on: September 18, 2012

Dual detection full range frequency domain optical coherence tomography.

Kye-Sung Lee1, Panomsak Meemon, William Dallas

  • 1The Institute of Optics, University of Rochester, Rochester, New York 14627, USA. kyelee4@gmail.com

Optics Letters
|April 6, 2010
PubMed
Summary
This summary is machine-generated.

Dual detection full range frequency domain optical coherence tomography (DD-FDOCT) overcomes mirror image issues in FD-OCT. This novel system provides full range imaging without speed loss and improved phase error tolerance.

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Area of Science:

  • Biomedical Optics
  • Optical Imaging
  • Metrology

Background:

  • Frequency domain optical coherence tomography (FD-OCT) offers higher sensitivity than time domain optical coherence tomography (OCT).
  • A key challenge in FD-OCT is the "mirror image" artifact, obscuring object structure due to Fourier transform properties.
  • Existing full range OCT systems may be sensitive to phase errors caused by subject motion.

Purpose of the Study:

  • To introduce a novel dual detection full range frequency domain optical coherence tomography (DD-FDOCT) system.
  • To address the mirror image artifact and improve phase error robustness in FD-OCT.
  • To enable instantaneous retrieval of complex interferometric signal quadrature components.

Main Methods:

  • Development of a novel DD-FDOCT system utilizing two detection arms.
  • Simultaneous acquisition of two signals with a phase difference of pi/2.
  • Implementation of a method to remove mirror images at all depths using the dual signals.

Main Results:

  • The DD-FDOCT system successfully retrieves quadrature components of the complex interferometric signal.
  • The system enables full range imaging without compromising imaging speed.
  • The DD-FDOCT system demonstrates reduced sensitivity to phase errors from involuntary movements.

Conclusions:

  • The DD-FDOCT system effectively eliminates the mirror image artifact in FD-OCT.
  • This technology offers robust full range imaging with high sensitivity and speed.
  • DD-FDOCT presents a significant advancement for optical coherence tomography applications sensitive to motion artifacts.