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Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Film Extrusion of Crambe abyssinica/Wheat Gluten Blends
06:51

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Published on: January 17, 2017

Process optimization for continuous extrusion wet granulation.

Li Tan1, Anthony J Carella, Yukun Ren

  • 1Pfizer Global R&D, Groton Laboratories, Groton, CT 06340, USA.

Pharmaceutical Development and Technology
|April 7, 2010
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Summary
This summary is machine-generated.

A polymethacrylate binder significantly improved acetaminophen tablet strength and disintegration compared to other binders. Extrusion granulation process parameters were optimized for enhanced granule properties and tablet performance.

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Area of Science:

  • Pharmaceutical Technology
  • Materials Science

Background:

  • Optimizing binder selection is crucial for high drug-load formulations.
  • Understanding granulation processes impacts tablet quality and performance.

Purpose of the Study:

  • Evaluate three granulating binders (polymethacrylate, polyvinylpyrrolidone, hydroxypropyl cellulose) in acetaminophen blends.
  • Investigate the effects of extrusion granulation parameters on granule properties.
  • Determine the optimal binder and process for robust tablet manufacturing.

Main Methods:

  • High shear granulation and extrusion granulation were employed.
  • A full factorial design studied extrusion parameters (granulating liquid, injection rate, screw speed).
  • Analyzed granule properties (density, particle size) and tablet characteristics (hardness, friability, disintegration, dissolution).

Main Results:

  • Polymethacrylate binder yielded tablets with superior tensile strength and rapid disintegration.
  • Polyvinylpyrrolidone and hydroxypropyl cellulose binders resulted in less optimal tablets.
  • Extrusion granulation parameters significantly influenced granule properties and tablet quality.

Conclusions:

  • Polymethacrylate is a promising binder for high drug-load acetaminophen tablets.
  • Optimized extrusion granulation can enhance tablet quality and manufacturing efficiency.
  • Binder choice and process control are critical for pharmaceutical formulation success.