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Prevalence, clinical characteristics and outcome in patients with chronic heart failure and diabetes

Chuan Shi1, Ling-jie Wang, Dan-feng Hu

  • 1Department of Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Chinese Medical Journal
|April 7, 2010
PubMed

Insights

The prevalence of chronic heart failure (CHF) with diabetes is rising, with these patients experiencing worse outcomes. Effective glucose-lowering treatments can improve cardiac function and reduce major cardiac events.

Area of Science:

  • Cardiology
  • Endocrinology
  • Public Health

Background:

  • Chronic heart failure (CHF) and diabetes mellitus share interrelated pathophysiologic processes, contributing to high morbidity and mortality.
  • Understanding the prevalence and characteristics of patients with both conditions is crucial for effective management.

Purpose of the Study:

  • To analyze the prevalence, clinical characteristics, and long-term outcomes of patients diagnosed with both CHF and diabetes mellitus.
  • To investigate the impact of glucose-lowering agents on cardiac function and major cardiac events in this patient population.

Main Methods:

  • A cohort of 1119 patients with NYHA functional class II-IV and left ventricular ejection fraction (LVEF) < 45% was retrospectively reviewed.
  • Clinical, biochemical, and echocardiographic data were collected, along with records of major cardiac events (MCE).

Main Results:

  • The prevalence of CHF with diabetes increased significantly over time and with age.
  • Patients with diabetes exhibited worse cardiac function, more abnormal biochemical markers, and higher mortality compared to those without diabetes.
  • Glucose-lowering agents improved LVEF and decreased MCE; elevated HbA1c was linked to adverse cardiac parameters and reduced survival. NYHA class and HbA1c >or= 7% were independent risk factors for adverse outcomes.

Conclusions:

  • The co-occurrence of CHF and diabetes is increasing, associated with poorer clinical profiles and prognosis.
  • Aggressive, integrated therapeutic strategies for both CHF and diabetes are essential to enhance patient outcomes.
Abstract

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