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Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Pharmacokinetic Models: Overview01:20

Pharmacokinetic Models: Overview

Pharmacokinetic models utilize mathematical analysis to achieve a detailed quantitative understanding of a drug's life cycle within the body. They are instrumental in simulating a drug's pharmacokinetic parameters, predicting drug concentrations over time, optimizing dosage regimens, linking concentrations with pharmacologic activity, and estimating potential toxicity.
There are three primary types of models: empirical, compartment, and physiological. Empirical models, with minimal assumptions,...
Pharmacokinetic Models: Comparison and Selection Criterion01:26

Pharmacokinetic Models: Comparison and Selection Criterion

Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
Mechanistic Models: Overview of Compartment Models01:21

Mechanistic Models: Overview of Compartment Models

Mechanistic models, a category encompassing both physiological and compartmental modeling, differ from empirical models' approaches to incorporating known factors about the systems being modeled. Empirical models describe data with minimal assumptions, while mechanistic models aim to provide a robust description of available data by specifying assumptions and integrating known factors about the system. Compartmental analysis is a key example of a mechanistic model in pharmacokinetics and...
Models of Health Promotion and Illness Prevention I01:25

Models of Health Promotion and Illness Prevention I

A model is a theoretical way to understand a concept or an idea. Models can overcome barriers to health regardless of diverse economic and cultural backgrounds. In addition, models make the task easier by providing different ways to approach complex issues. There are two major health promotion models: the health belief model and the health promotion model.
The health belief model (HBM) attempts to predict health-related behavior in specific belief patterns. According to the HBM, a person's...

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Related Experiment Video

Updated: Jun 14, 2026

Working with Human Tissues for Translational Cancer Research
07:48

Working with Human Tissues for Translational Cancer Research

Published on: November 26, 2015

Changing models of biomedical research.

William F Crowley1, James F Gusella

  • 1Harvard Reproductive Endocrine Sciences Center, Department of Medicine, Massachusetts General Hospital, Department of Genetics, Harvard Medical School, Boston, MA 02114, USA. wcrowley@partners.org

Science Translational Medicine
|April 7, 2010
PubMed
Summary

Academic health centers (AHCs) must adapt infrastructures to translate basic science into clinical applications and patient care. Systemic investments are crucial for human investigation and supporting physician-scientist careers.

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Area of Science:

  • Biomedical Research
  • Translational Science
  • Health Care Innovation

Background:

  • Academic health centers (AHCs) possess potential for advancing translational science due to technological and research progress.
  • Traditional AHC infrastructures primarily support basic research, not the full spectrum of translational activities.

Purpose of the Study:

  • To highlight the need for AHC infrastructure modifications to support expanded translational roles.
  • To identify critical needs for advancing human investigation and physician-scientist careers in translational research.

Main Methods:

  • The abstract discusses the evolving landscape of academic health centers.
  • It reviews the challenges and requirements for effective translational research.

Main Results:

  • AHCs must evolve from basic research hubs to comprehensive translational engines.
  • Significant infrastructure and career support investments are necessary for AHCs to fulfill their translational potential.

Conclusions:

  • Adapting AHC infrastructures is essential for translating scientific discoveries into improved patient outcomes.
  • Addressing challenges in human investigation and physician-scientist career development requires systemic investment.