Related Experiment Video
Updated: Jun 14, 2026

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
[Expression and significance of P53 and P21 in nasal NK/T-cell lymphoma]
Gang Xu1, Huai-Fu Wang, Gang He
1Department of Otolaryngology, Sichuan Academy of Medical Sciences, Sichuan Provincial People' s Hospital, Chengdu 610072, China.
Objective:
To investigate the significance of P53 and P21 expressions in nasal NK/T-cell lymphoma (NKTL) and their relationships with the clinical stage, prognosis, proliferation and apoptosis of tumor cells.
Methods:
The clinicopathologic and follow-up data was collected from 62 patients with NKTL proven by pathological examination. Sixty-two cases of NKTL were examined for P53, P21 and Ki67 proteins with tissue microarray technique and immunohistochemistry. TUNEL method was used to detect apoptosis (apoptosis index, AD). The proliferation index (PI) was determined by the expression of Ki67 proteins.
Results:
The positive rates of P53 and P21 protein expression in NKTL were 79.03% and 58.06% respectively. The positive rates of P53 in Ann Arbor stage I, II, III and lV NKTL were 69.57%, 75.00%, 86.67% and 100.00% respectively, while those of P21 were 47.83%, 56.25%, 60.00% and 87.50%. With the progression of tumor, the positive expression rates of P53 and P21 proteins gradually increased. And there were significant differences statistically between the expressions of P53/ P21 and Ann Arbor stage (P < 0.05). The expression of P53 was positively correlated with the expression of P21(r = 0.467, P < 0.05). The prognosis of P53 and P21 positive expression group was worse than that of negative expression group (P < 0.05). The expression of P53 protein was an independent prognostic factor. The intensities of P53 and P21 expressions were positively correlated with PI (r = 0.177, 0.184, P < 0.05), while not correlated with AI (P > 0.05).
Conclusion:
The expressions of P53, P21 and Ki67 proteins are closely related with the pathogenesis and progression of NKTL. Combined detection of P53, P21 and Ki67 could be better to judge the biological behavior of NKTL.
Related Concept Videos
Abnormal Proliferation
Negative Regulator Molecules
Interactions Between Signaling Pathways
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
