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Reduction of cerebral glucose utilization by the HIV envelope glycoprotein Gp-120
A S Kimes1, E D London, G Szabo
1Neuropharmacology Laboratory, National Institute on Drug Abuse, Baltimore, Maryland 21224.
Experimental Neurology
|May 1, 1991
Abstract:
Gp-120 is a glycoprotein constituent of the human immunodeficiency virus (HIV) envelope. The effects of gp-120 on cerebral glucose utilization in rats were studied by the quantitative 2-deoxy-D-[1-14C] glucose method. Intracerebroventricular injection of gp-120 significantly reduced glucose utilization in the lateral habenula and the suprachiasmatic nucleus and decreased the global cerebral metabolic rate for glucose. The findings suggest that gp-120 and closely related peptides can alter neuronal function, thereby contributing to the sequelae of HIV infection.