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Related Experiment Videos

Impulsivity, Stimulant Abuse, and Dopamine Receptor Signaling.

E D London1

  • 1Brain Research Institute, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, United States.

Advances in Pharmacology (San Diego, Calif.)
|June 12, 2016
PubMed
Summary

Treating amphetamine use disorder is challenging due to dopamine system dysfunction and impulsivity. Exercise training may enhance dopamine D2 receptor signaling, offering a promising adjunct therapy for addiction.

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Area of Science:

  • Neuroscience and Addiction Research
  • Pharmacology and Behavioral Science

Background:

  • Nonmedical amphetamine-type stimulant use is a global issue with significant health and social impacts.
  • Amphetamine use disorder lacks effective pharmacological treatments, partly due to dopamine system dysfunction and impulsivity in users.
  • Impulsive behaviors in stimulant users can hinder the success of addiction treatments.

Purpose of the Study:

  • To review the role of dopaminergic neurotransmission in impulsivity among healthy individuals and methamphetamine-dependent users.
  • To explore the contribution of dopamine D1 and D2 receptor signaling to self-control and impulsivity in methamphetamine dependence.
  • To identify potential therapeutic targets for amphetamine use disorder.

Main Methods:

  • Review of existing scientific literature on dopaminergic neurotransmission, impulsivity, and stimulant use disorder.
Keywords:
AddictionCorticostriatalDopamineMagnetic resonance imagingMethamphetaminePositron emission tomographyStimulant

Related Experiment Videos

  • Analysis of findings related to dopamine D1 and D2 receptor signaling in methamphetamine-dependent individuals.
  • Evaluation of the effectiveness of current and potential therapeutic strategies.

    • Main Results:

    • Striatal D2-type dopamine receptors are implicated as a potential therapeutic target for stimulant use disorders.
    • Existing medications targeting D2-type receptors have shown limited success, possibly due to receptor downregulation.
    • Exercise training is emerging as a promising adjunct therapy to behavioral treatments for addiction.

    Conclusions:

    • Augmenting D2-type dopamine receptor signaling is a key consideration for treating stimulant use disorders.
    • Exercise training presents a viable strategy to enhance D2-type receptor signaling and support addiction treatment.
    • Further research into non-pharmacological interventions like exercise is warranted for amphetamine use disorder.