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Updated: Feb 4, 2026

Detection of Protein Aggregation using Fluorescence Correlation Spectroscopy
Published on: April 25, 2021
Calix[4]arene sulfonate as a template for forming fluorescent thiazole orange H-aggregates
1Chemistry Department, University of Calgary, 2500 University drive N.W., T2N 1N4, Calgary, Canada.
Abstract:
The unexpected interaction between thiazole orange (TO) and calix[4]arene sulfonate is reported herein. H-Aggregates of TO switching on their fluorescence in solution are observed. Surprisingly, fluorescence enhancement is not linked to host-guest inclusion, but rather to calix[4]arene sulfonate serving as a template for several TO molecules.
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