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Updated: Jun 14, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Generalized granuloma annulare presenting as arcuate dermal erythema
V Milicić1, A Ravić-Nikolić, B Jovović-Dagović
1Department of Dermatology, Kragujevac Clinical Center, Zmaj Jovina 30, 34000 Kragujevac, Serbia. vesna.milicic@sbb.rs
Abstract:
Generalized granuloma annulare (GGA) is an uncommon cutaneous disease of unknown origin, characterized by numerous flesh-colored to erythematous papules with or without annular configuration. Clinical associations of GGA with diabetes mellitus, thyroid diseases, malignancies, AIDS, and chronic hepatitis C virus infection have been reported. Therapy has been attempted with various modalities with moderate efficacy. We report a case of GGA presenting as arcuate dermal erythema with excellent therapeutic response to corticosteroid therapy (a short course of intramuscular corticosteroids, a prolonged low oral dose, and topical corticosteroids).
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