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Updated: Jun 14, 2026

An ELISA Based Binding and Competition Method to Rapidly Determine Ligand-receptor Interactions

An ELISA Based Binding and Competition Method to Rapidly Determine Ligand-receptor Interactions

Published on: March 14, 2016

Integrative genomic analyses on IL28RA, the common receptor of interferon-lambda1, -lambda2 and -lambda3.

Liming Yang¹, Yuming Luo, Jifu Wei

¹School of Life Sciences, Huaiyin Normal University, Nanjing 210029, PR China.

International Journal of Molecular Medicine

|April 8, 2010

Summary

This summary is machine-generated.

Interferon (IFN)-lambdas are cytokines that bind to IL28RA receptors for antiviral and antitumor effects. This study identified IL28RA genes across species and found their expression linked to cancer prognosis and immune cell differentiation.

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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Area of Science:

Immunology
Genetics
Molecular Biology

Background:

Interferon (IFN)-lambdas (IFN-λ1, IFN-λ2, IFN-λ3) are cytokines related to type I IFNs and IL-10.
These cytokines exert antiviral, antitumor, and immunomodulatory effects by binding to the IL28RA receptor.

Purpose of the Study:

To identify IL28RA genes across various species.
To investigate the expression patterns of human IL28RA.
To analyze the prognostic value of IL28RA in cancer and its regulatory mechanisms.

Main Methods:

Bioinformatic identification of IL28RA genes in human, chimpanzee, macaque, orangutan, mouse, horse, rat, dog, and chicken genomes.
Analysis of human IL28RA gene expression in various tissues and cancers.
Identification of transcriptional factor binding sites in the promoter region of human IL28RA.
Meta-analysis of IL28RA gene expression and cancer prognosis.

Main Results:

A single IL28RA gene was identified in each of the studied genomes, with most being single-pass type I membrane proteins.
Human IL28RA expression was detected in lymphoid tissues, testes, certain cancers, and embryonic/fetal tissues.
Tumor-related transcriptional factor binding sites (AP-2, c-Jun, P53) and immune cell differentiation-related sites (STAT1, LyF-1) were identified in the IL28RA promoter region.
Meta-analysis confirmed a correlation between IL28RA expression and prognosis in specific cancers.

Conclusions:

IL28RA is a conserved gene across species, playing a role in immune responses and cancer.
IL28RA expression is linked to cancer prognosis, suggesting its potential as a biomarker.
The promoter region of IL28RA contains binding sites for transcription factors that regulate its expression and mediate IFN-lambda effects in immunity and cell differentiation.