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Updated: Jun 14, 2026
10:51
Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
Published on: November 15, 2013
Orphan nuclear receptors as targets for drug development
Subhajit Mukherjee1, Sridhar Mani
1Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Chanin 302-D1, Bronx, New York 10461, USA.
Pharmaceutical Research
|April 8, 2010
Summary
Orphan nuclear receptors are crucial transcription factors sensing hormones and xenobiotics. Targeting these receptors with novel drugs offers promising therapeutic strategies for various human diseases.
Area of Science:
- Endocrinology and Molecular Biology
- Pharmacology
Background:
- Orphan nuclear receptors are key regulators of diverse biological processes.
- They function as ligand-activated transcription factors, sensing steroid hormones and xenobiotics.
- Their involvement in novel signaling pathways makes them attractive therapeutic targets.
Purpose of the Study:
- To review the physiological and pathophysiological roles of orphan nuclear receptors.
- To explore the potential of targeting these receptors for drug development.
- To highlight xenobiotics that modulate orphan nuclear receptor activity.
Main Methods:
- Literature review of studies on orphan nuclear receptors.
- Analysis of signaling pathways regulated by these receptors.
- Identification of xenobiotic compounds targeting orphan nuclear receptors.
Main Results:
- Orphan nuclear receptors are implicated in numerous physiological and pathophysiological conditions.
- Various xenobiotics have been identified that interact with these receptors.
- These interactions suggest potential therapeutic applications.
Conclusions:
- Orphan nuclear receptors play critical roles in health and disease.
- Exploiting their functions through xenobiotic modulation can lead to the development of new drugs.
- Targeting orphan nuclear receptors represents a promising avenue for treating human diseases.
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