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Updated: Jun 14, 2026
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Fabrication of Small Caliber Stent-grafts Using Electrospinning and Balloon Expandable Bare Metal Stents
Published on: October 26, 2016
Construction of small-caliber, polydioxanone cyclohexanone vascular stents
Qingjun You1, Feng Wang, Liang Duan
1Cardiothoracic Surgery Department, Affiliated No. 4 Hospital, Suzhou University, Wu Xi, Jiang Su, 214062, People's Republic of China.
Cell Biochemistry and Biophysics
|April 8, 2010
Summary
This study developed a novel three-layered artificial vascular stent using small intestine submucosa (SIS) and polydioxanone (PDS). The PDS stent demonstrated promising biomechanical properties and biocompatibility, suggesting potential for future clinical applications.
Area of Science:
- Biomaterials Science
- Vascular Surgery
- Tissue Engineering
Background:
- Development of small-caliber artificial vascular grafts remains a significant challenge.
- Existing synthetic grafts often face issues with biocompatibility and long-term patency.
- Need for innovative biomaterials that promote tissue integration and vascularization.
Purpose of the Study:
- To construct and characterize a novel three-layered artificial vascular stent.
- To evaluate the biocompatibility, degradation, and biomechanical properties of the PDS stent.
- To assess the potential of this artificial stent for future clinical applications.
Main Methods:
- Constructed a three-layered stent with small intestine submucosa (SIS) and polydioxanone (PDS).
- Performed cytotoxicity assays (MTT) and histological/microscopy analyses for degradation.
- Evaluated biomechanical properties including burst pressure, rupture intensity, strain ratio, and radial compliance in canine models.
Main Results:
- The PDS stent exhibited biomechanical properties comparable to physiological vessels.
- Cytotoxicity tests confirmed the stent's suitability for medical applications (toxicity 0-1).
- Histological analysis showed tissue integration, with SIS replaced by fibrous tissue and gradual PDS degradation over 24 weeks.
Conclusions:
- The developed artificial vascular stent demonstrates favorable biomechanical performance and biocompatibility.
- The PDS stent shows potential for successful tissue integration and remodeling in vivo.
- Further investigation is warranted for its clinical translation in vascular reconstructive surgery.
