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Related Experiment Video

Updated: Jun 14, 2026

Motor Imagery Brain-Computer Interface in Rehabilitation of Upper Limb Motor Dysfunction After Stroke
09:42

Motor Imagery Brain-Computer Interface in Rehabilitation of Upper Limb Motor Dysfunction After Stroke

Published on: September 1, 2023

Resting interhemispheric functional magnetic resonance imaging connectivity predicts performance after stroke.

Alex R Carter1, Serguei V Astafiev, Catherine E Lang

  • 1Department of Neurology, Washington University School of Medicine, 4525 Scott Avenue, St. Louis, MO 63110, USA.

Annals of Neurology
|April 8, 2010
PubMed
Summary

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Stroke lesions disrupt brain networks, impacting behavior. Interhemispheric functional connectivity (FC) changes correlate with attention and motor deficits, highlighting its clinical importance for stroke recovery.

Area of Science:

  • Neuroscience
  • Neurology
  • Medical Imaging

Background:

  • Focal brain lesions can cause remote functional deficits.
  • Network dysfunction following stroke significantly contributes to behavioral impairments.
  • Resting-state functional connectivity (FC) measures spontaneous brain activity.

Purpose of the Study:

  • Investigate the behavioral significance of altered functional connectivity (FC) after stroke.
  • Correlate FC changes in specific brain networks with behavioral performance.
  • Compare the behavioral relevance of intrahemispheric versus interhemispheric FC.

Main Methods:

  • Measured FC in dorsal attention and somatomotor networks using fMRI in acute stroke patients.
  • Assessed attention and motor function through separate behavioral tests.

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Last Updated: Jun 14, 2026

Motor Imagery Brain-Computer Interface in Rehabilitation of Upper Limb Motor Dysfunction After Stroke
09:42

Motor Imagery Brain-Computer Interface in Rehabilitation of Upper Limb Motor Dysfunction After Stroke

Published on: September 1, 2023

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke
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Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke

Published on: July 14, 2023

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  • Analyzed correlations between FC and behavioral outcomes, distinguishing intra- and interhemispheric connections.

    • Main Results:

    • Disrupted interhemispheric FC in the attention network correlated with visual detection deficits.
    • Impaired interhemispheric FC in the somatomotor network correlated with upper extremity impairment.
    • Intrahemispheric FC showed no correlation with behavioral performance; results were independent of lesion size.

    Conclusions:

    • Brain lesions alter spontaneous functional architecture and constrain behavior.
    • Interhemispheric interactions are crucial for behavioral output post-stroke.
    • FC is a valid clinical tool for assessing brain network health, prognosis, and recovery.