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Updated: Jun 14, 2026

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
Published on: January 29, 2018
Reduced bone density in individuals with severe hemophilia B
Hassan Mansouritorghabeh1, Zahra Rezaieyazdi, Nayyereh Saadati
1Immunology Research Center, Ghaem Hospital, Mashhad, Iran. Mansouritorghabe@mums.ac.ir
Aim:
The reduced bone density in individuals with severe hemophilia A (decreased coagulation factor VIII level) and combined factor V and VIII deficiency have been reported. In the current case-control study we tried to address bone mineral density in individuals with severe hemophilia B (decreased coagulation factor IX).
Methods:
In our case-control study, we recruited bone density and biochemical indexes in 14 individuals with severe hemophilia B and compared obtained results with 14 age- and sex-matched control group results.
Results:
Our results showed individuals with severe hemophilia B had reduced bone density in lumbar (-0.34 +/- 0.97) and femur (-0.82 +/- 1.37) regions, compared to the control group (0.84 +/- 0.53 and 1.02 +/- 1.04 respectively; P-value = 0.000 and 0.000).
Conclusion:
The foremost complication of coagulation disorders are various types of excessive bleedings. The current study revealed severe hemophiliac B patients are prone to reduced bone density similar to severe hemophiliac A patients.
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