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Regulation of metabolism by nuclear hormone receptors

Huey-Jing Huang1, Ira G Schulman

  • 1Department of Biology, Exelixis Inc., 4757 Nexus Centre Drive, San Diego, California 92121, USA.

Progress in Molecular Biology and Translational Science
|April 9, 2010
PubMed

Insights

Nuclear hormone receptors are key regulators of metabolism and inflammation. Understanding these pathways is crucial for developing new treatments for metabolic diseases.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Metabolic Disease Research

Background:

  • Metabolic diseases represent a global health crisis, necessitating a deeper understanding of their underlying pathogenesis.
  • Nuclear hormone receptors are critical transcription factors controlling development, differentiation, and metabolism.
  • Numerous nuclear receptors coordinating genetic networks for lipid metabolism and energy utilization have been identified.

Purpose of the Study:

  • To discuss the role of nuclear hormone receptors in regulating metabolism and inflammation.
  • To highlight the potential of nuclear receptor subfamilies as therapeutic targets for metabolic diseases.

Main Methods:

  • Review of literature on nuclear hormone receptors and their role in metabolic regulation.
  • Analysis of mechanisms by which nuclear receptors sense metabolic intermediates or protein interactions.
  • Discussion of the impact of nuclear receptors on metabolism and inflammation.

Main Results:

  • Nuclear hormone receptors directly sense metabolic intermediates or indirectly via protein interactions to regulate metabolic pathways.
  • These receptors play a significant role in coordinating genetic networks governing lipid metabolism and energy utilization.
  • Specific nuclear receptor subfamilies show promise as targets for therapeutic intervention in metabolic disorders.

Conclusions:

  • Nuclear hormone receptors are vital regulators of metabolic homeostasis and inflammation.
  • Targeting specific nuclear receptor subfamilies offers a promising strategy for treating metabolic diseases.
  • Further research into these receptors can lead to novel therapeutic approaches for a range of metabolic conditions.

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