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Related Concept Videos

Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
General Anesthesia: Overview01:24

General Anesthesia: Overview

Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...

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Related Experiment Video

Updated: Jun 14, 2026

Innovative Strategies for Organ Preservation in Heart Transplantation: Uniform Cooling Preservation and Ex-situ Normothermic Perfusion
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Innovative Strategies for Organ Preservation in Heart Transplantation: Uniform Cooling Preservation and Ex-situ Normothermic Perfusion

Published on: November 28, 2025

Anesthetic optimization for nonheartbeating donors.

Vito Fanelli1, Luciana Mascia

  • 1Dipartimento di Anestesiologia e Rianimazione, Università di Torino, Ospedale S. Giovanni Battista-Molinette, Torino, Italy.

Current Opinion in Anaesthesiology
|April 9, 2010
PubMed
Summary
This summary is machine-generated.

Donation after cardiac death (DCD) offers a new strategy to increase organ availability for transplantation. Careful management and ethical considerations are crucial for optimizing DCD donor care and procurement.

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Last Updated: Jun 14, 2026

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Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death
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Published on: August 15, 2022

Area of Science:

  • Transplantation Medicine
  • Organ Donation
  • Cardiology

Background:

  • Donors after cardiac death (DCD) represent an underutilized resource to expand the organ donor pool.
  • Effective management of DCD requires prompt identification and specialized care to optimize organ viability.

Purpose of the Study:

  • To review the strategies and implications of increasing organ donation through donors after cardiac death.
  • To highlight the necessary interventions and ethical considerations for managing non-heart-beating donors.

Main Methods:

  • Review of current practices and policies in major transplantation centers regarding DCD.
  • Analysis of the conditions and procedures for organ procurement from DCDs.
  • Discussion of ethical and practical challenges associated with DCD.

Main Results:

  • Organ procurement from DCDs is increasingly adopted by major transplant hospitals.
  • Key donor profiles include patients with irreversible brain injuries or high spinal cord injuries.
  • Procurement requires independent withdrawal of life support, careful management of withdrawal symptoms, and confirmation of cardiac death for 2-5 minutes.

Conclusions:

  • Donation after cardiac death is a proposed strategy to enhance organ availability for transplantation.
  • Comprehensive understanding of DCD protocols and ethical considerations is vital for transplant teams.
  • Further research is needed on long-term outcomes and ethical aspects across diverse religious and cultural backgrounds.