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Published on: May 9, 2022
Gene therapy and its implications in Periodontics.
Swapna Mahale1, Nitin Dani, Shumaila S Ansari
1Professor and Guide, MGV's KBH Dental College and Hospital, Panchavati, Nashik - 422 003, Maharashtra, India.
Journal of Indian Society of Periodontology
|April 9, 2010
Summary
Gene therapy offers new ways to treat periodontal diseases and rebuild dental structures. Future strategies focus on enhancing host defenses and developing periodontal vaccines.
Area of Science:
- Biomedicine
- Periodontics
- Gene Therapy
Background:
- Gene therapy is advancing dental applications, particularly in managing periodontal diseases and reconstructing the dento-alveolar apparatus.
- Periodontal diseases present complex challenges requiring innovative treatment modalities.
Purpose of the Study:
- To review the current and future applications of gene therapy in periodontics.
- To highlight gene therapy's role in tissue engineering and combating biofilm antibiotic resistance.
Main Methods:
- Review of existing literature on gene therapy in periodontics.
- Discussion of gene therapy approaches including cell-based, protein-based, and gene delivery.
- Exploration of genetic strategies for addressing biofilm antibiotic resistance.
Main Results:
- Gene therapy facilitates tissue engineering in periodontics through multiple approaches.
- Genetic interventions show promise in overcoming antibiotic resistance in periodontal biofilms.
- Future strategies involve enhancing host defense mechanisms and periodontal vaccination.
Conclusions:
- Gene therapy is an emerging and significant tool in periodontics.
- It offers novel strategies for disease control, tissue regeneration, and infection prevention.
- Further research into periodontal gene therapy holds potential for improved patient outcomes.
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