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Related Concept Videos

Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...

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Related Experiment Video

Updated: Jun 14, 2026

Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation
06:04

Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation

Published on: August 8, 2025

[Transcatheter aortic valve implantation].

Helge Möllmann1, Jörg Kempfert, Christian W Hamm

  • 1Kerckhoff-Klinik, Herz- und Thoraxzentrum Bad Nauheim, Bad Nauheim, Germany. h.moellmann@kerckhoff-fgi.de

Herz
|April 9, 2010
PubMed
Summary

Transcatheter aortic valve implantation offers a vital alternative for patients with severe aortic stenosis ineligible for surgery. This minimally invasive approach shows promise, though further trials are needed to confirm its safety and effectiveness.

Related Experiment Videos

Last Updated: Jun 14, 2026

Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation
06:04

Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation

Published on: August 8, 2025

Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Biomedical Engineering

Context:

  • Degenerative aortic valve stenosis is the most common native valve disease, with poor prognosis for untreated symptomatic patients.
  • An aging population is increasing the incidence of symptomatic aortic stenosis.
  • Surgical aortic valve replacement is effective but carries high risks for elderly patients with comorbidities, excluding one-third from treatment.

Purpose:

  • To evaluate transcatheter aortic valve implantation (TAVI) as a therapeutic option for patients with severe aortic stenosis unsuitable for traditional surgery.
  • To describe the principles and current status of TAVI procedures using available prostheses.

Summary:

  • Transcatheter off-pump aortic valve implantation, via transfemoral or transapical routes, provides an alternative for high-risk surgical candidates.
  • Approved devices like the Edwards-SAPIEN and Medtronic Core-Valve are implanted after predilation of the native valve during ventricular pacing.
  • Current registries report 30-day mortality rates of 8-15% in higher-risk populations.

Impact:

  • TAVI expands treatment options for severe aortic stenosis in patients who are poor surgical candidates.
  • While promising, larger randomized trials are essential to definitively establish the safety and efficacy of TAVI.
  • This technology addresses a growing clinical need driven by demographic changes.