Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...
Protein-Protein Interfaces02:04

Protein-Protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Self-supported catalysts.

Chemical reviews·2008
Same author

[The local control of radiotherapy following Ivor-Lewis esophagectomy in the patients with stage II A middle-third thoracic esophageal cancer].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2008
Same author

Magnetic loading of carbon nanotube/nano-Fe(3)O(4) composite for electrochemical sensing.

Talanta·2008
Same author

Carbon nanotube/polystyrene composite electrode for microchip electrophoretic determination of rutin and quercetin in Flos Sophorae Immaturus.

Talanta·2008
Same author

[Observation on efficacy of large volume whole lung lavage in treatment of pneumoconiosis].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases·2008
Same author

[Application of large volume whole lung lavage in pneumoconiosis].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases·2008
Same journal

DiffGRN: differential gene regulatory network analysis.

International journal of data mining and bioinformatics·2019
Same journal

Integration of multi-omics data for integrative gene regulatory network inference.

International journal of data mining and bioinformatics·2018
Same journal

The development of non-coding RNA ontology.

International journal of data mining and bioinformatics·2016
Same journal

Learning multiple distributed prototypes of semantic categories for named entity recognition.

International journal of data mining and bioinformatics·2015
Same journal

Weighted fusion regularisation and predicting microbial interactions with vector autoregressive model.

International journal of data mining and bioinformatics·2015
Same journal

Application of consensus string matching in the diagnosis of allelic heterogeneity involving transposition mutation.

International journal of data mining and bioinformatics·2015
See all related articles

Related Experiment Video

Updated: Jun 14, 2026

Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay (PCA) in Living Cells
08:38

Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay (PCA) in Living Cells

Published on: March 3, 2015

Identifying the overlapping complexes in protein interaction networks.

Min Li1, Jianxin Wang, Jianer Chen

  • 1School of Information Science and Engineering, Central South University, Changsha 410083, China. limin@mail.csu.edu.cn

International Journal of Data Mining and Bioinformatics
|April 9, 2010
PubMed
Summary
This summary is machine-generated.

This study introduces a new algorithm, Identifying Protein Complexes based on Maximal Clique Extension (IPC-MCE), to find protein complexes in cellular networks. The method successfully identified known protein complexes in yeast, aiding in understanding cell organization.

More Related Videos

Resolving Affinity Purified Protein Complexes by Blue Native PAGE and Protein Correlation Profiling
09:35

Resolving Affinity Purified Protein Complexes by Blue Native PAGE and Protein Correlation Profiling

Published on: April 1, 2017

Identification of Protein Complexes in Escherichia coli using Sequential Peptide Affinity Purification in Combination with Tandem Mass Spectrometry
14:58

Identification of Protein Complexes in Escherichia coli using Sequential Peptide Affinity Purification in Combination with Tandem Mass Spectrometry

Published on: November 12, 2012

Related Experiment Videos

Last Updated: Jun 14, 2026

Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay (PCA) in Living Cells
08:38

Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay (PCA) in Living Cells

Published on: March 3, 2015

Resolving Affinity Purified Protein Complexes by Blue Native PAGE and Protein Correlation Profiling
09:35

Resolving Affinity Purified Protein Complexes by Blue Native PAGE and Protein Correlation Profiling

Published on: April 1, 2017

Identification of Protein Complexes in Escherichia coli using Sequential Peptide Affinity Purification in Combination with Tandem Mass Spectrometry
14:58

Identification of Protein Complexes in Escherichia coli using Sequential Peptide Affinity Purification in Combination with Tandem Mass Spectrometry

Published on: November 12, 2012

Area of Science:

  • * Computational biology
  • * Systems biology
  • * Bioinformatics

Background:

  • * Understanding cellular organization and protein functions relies on identifying protein complexes within large interaction networks.
  • * Existing methods may have limitations in accurately detecting these complexes.

Purpose of the Study:

  • * To propose a novel algorithm, Identifying Protein Complexes based on Maximal Clique Extension (IPC-MCE), for robust protein complex detection.
  • * To leverage the concept of maximal cliques as the core of protein complexes and define relationships using Interaction Probability.

Main Methods:

  • * Development of the IPC-MCE algorithm, which identifies protein complexes by extending maximal cliques.
  • * Classification of proteins within a complex into core and peripheral vertices.
  • * Quantification of the relationship between core and peripheral vertices using Interaction Probability.

Main Results:

  • * Application of the IPC-MCE algorithm to the protein interaction network of Saccharomyces cerevisiae.
  • * Successful detection of numerous well-established protein complexes within the yeast interactome.
  • * Demonstration of the algorithm's efficacy in identifying biologically relevant protein assemblies.

Conclusions:

  • * The IPC-MCE algorithm provides an effective approach for identifying protein complexes in large biological networks.
  • * The findings contribute to a better understanding of cellular organization and protein function prediction.
  • * This method offers a valuable tool for systems biology research.