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Updated: Jun 14, 2026
06:38
An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
Published on: September 12, 2019
[Targeted therapies in hepatocellular carcinoma]
Mohamed Bouattour1, Hélène Marijon, Chantal Dreyer
1Service inter-hospitalier de cancérologie Bichat-Beaujon, hôpital Beaujon, 92110 Clichy, France.
Presse Medicale (Paris, France : 1983)
|April 10, 2010
Summary
Hepatocellular carcinoma (HCC) management improved with targeted therapies like sorafenib, showing survival benefits in advanced cases. Further research into signaling pathways aims to expand future HCC treatment options.
Area of Science:
- Hepatocellular carcinoma (HCC) research
- Oncology
- Molecular targeted therapy
Background:
- Hepatocellular carcinoma (HCC) is a significant global health concern.
- Conventional chemotherapy has shown limited efficacy in advanced HCC.
- Recent advancements focus on understanding molecular pathways in HCC development.
Purpose of the Study:
- To review clinical trials evaluating targeted therapies for advanced HCC.
- To explore how knowledge of deregulated signaling pathways can improve HCC treatment.
- To assess the potential of new targeted therapies to expand treatment options for HCC.
Main Methods:
- Review of clinical trial data for targeted therapies in HCC.
- Analysis of the impact of signaling pathway research on HCC management.
- Evaluation of sorafenib's efficacy based on SHARP and Asian-Pacific trials.
Main Results:
- Sorafenib demonstrated an overall survival benefit in advanced HCC patients.
- Targeted therapies represent a shift from conventional cytotoxic chemotherapies.
- Understanding molecular pathways is crucial for therapeutic advancements in HCC.
Conclusions:
- Targeted therapies, exemplified by sorafenib, offer improved outcomes for advanced HCC.
- Continued research into molecular signaling pathways is essential for developing novel HCC treatments.
- The therapeutic armamentarium for HCC is expanding with the evaluation of new targeted agents.
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