[Autoimmune thyroid disorders and reproductive failures].

Area of Science:

• Endocrinology
• Immunology
• Reproductive Medicine

Context:

• Thyroid autoimmunity's role in pregnancy has gained attention over the last decade.
• Subtle thyroid autoimmunity, even without overt dysfunction, is linked to fertility issues.
• Thyroid autoimmunity is associated with recurrent pregnancy loss.

Purpose:

• To explore the influence of thyroid autoantibodies on pregnancy.
• To highlight the risks of subfertility and recurrent pregnancy loss due to thyroid autoimmunity.
• To propose screening and treatment strategies for managing thyroid autoimmunity in pregnancy.

Summary:

• Thyroid autoantibodies can negatively affect normal pregnancy initiation, development, and progression.
• Alterations in thyroid autoimmunity increase the risk of subfertility and recurrent pregnancy loss.
• While the exact mechanism is unknown, thyroid autoantibodies may trigger immune responses disrupting maternal-fetal thyroid function.

Impact:

• Systematic screening for thyroid dysfunction and antibodies in early gestation is recommended.
• Prompt administration of levothyroxine treatment can prevent adverse pregnancy outcomes.
• Understanding and managing thyroid autoimmunity is crucial for successful pregnancy management.