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Follicular non-Hodgkin's lymphoma.
D Hayashi1, J C Lee, B Devenney-Cakir
1Department of Radiology, Boston University School of Medicine, FGH Building, 3rd Floor, Boston, MA 02118, USA. Daichi.Hayashi@bmc.org
Clinical Radiology
|April 13, 2010
Summary
Follicular non-Hodgkin's lymphoma (NHL) is an indolent cancer. This review details its characteristics, prognostic index (FLIPI-2), and imaging findings for better patient management and treatment selection.
Area of Science:
- Hematology
- Oncology
- Radiology
Background:
- Follicular non-Hodgkin's lymphoma (NHL) is characterized by its indolent nature, incurability, and propensity for residual disease post-treatment.
- This subtype may transform into more aggressive forms of lymphoma, necessitating careful monitoring and management strategies.
Observation:
- Histological and flow cytometry features define follicular NHL.
- The Follicular Lymphoma International Prognostic Index 2 (FLIPI-2) aids in treatment selection and patient stratification for clinical trials.
- Characteristic imaging appearances across ultrasound, CT, MRI, and PET/CT are crucial for diagnosis and follow-up.
Findings:
- Nodal and extranodal follicular NHL exhibit distinct imaging patterns, correlated with pathological findings.
- Imaging plays a pivotal role throughout the management of follicular lymphoma patients.
- Awareness of potential active residual masses, indolent recurrence, and transformation is vital for radiologists.
Implications:
- Improved prognostic tools and targeted therapies enhance overall survival rates for follicular lymphoma.
- Radiologists must be vigilant for recurrence, transformation, and potential co-existing primary cancers in treated patients.
- Accurate imaging interpretation is essential for guiding therapeutic decisions and improving patient outcomes in follicular lymphoma.
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