Related Experiment Video
Updated: Jun 14, 2026
10:28
Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
Published on: September 20, 2018
Coordinated control of the gene expression machinery
Robert J White1, Andrew D Sharrocks
1Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK.
Trends in Genetics : TIG
|April 13, 2010
Summary
Gene expression control involves coordinated steps from DNA transcription to protein production. Signal transduction pathways, like MAP kinase and mTOR, integrate cellular responses at transcriptional and post-transcriptional levels.
Area of Science:
- Molecular Biology
- Cell Biology
- Genetics
Background:
- Gene expression is a complex, multi-step process essential for cellular function.
- Coordinated control of gene expression ensures proper cellular function and phenotype.
- Signal transduction pathways play a critical role in regulating gene expression.
Purpose of the Study:
- To elucidate how signal transduction pathways achieve integrated control of gene expression.
- To highlight the coordination between transcription, RNA processing, and translation.
Main Methods:
- Review of recent studies on MAP kinase and mTOR signaling pathways in mammalian cells.
- Analysis of transcriptional regulation by RNA polymerases I-III.
- Examination of the link between transcription and downstream RNA processing and translation.
Main Results:
- Signal transduction pathways orchestrate wholesale changes in cellular gene expression profiles.
- Integrated responses are achieved through coordinate regulation of RNA polymerases I-III.
- Coordination extends from transcription to RNA processing and translation.
Conclusions:
- Signal transduction pathways provide a mechanism for coordinated gene expression control.
- This coordination ensures the precise execution of cellular functions and phenotype determination.
- Understanding these pathways offers insights into cellular responses to stimuli.
Related Concept Videos
02:33Combinatorial Gene Control
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
02:24Regulation of Expression Occurs at Multiple Steps
Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
02:24Regulation of Expression Occurs at Multiple Steps
Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
01:29Coordination of Gene Expression Processes in Bacteria
The DNA replication, transcription, and translation processes are intricately coupled in bacteria, allowing efficient gene expression and rapid protein synthesis. While this physical and functional coordination is advantageous, it introduces challenges that bacteria overcome through specific regulatory mechanisms.Coupling of Replication, Transcription, and TranslationThe coupling of replication, transcription, and translation is a hallmark of bacterial gene expression. As the replisome unwinds...
01:23Regulation of Expression at Multiple Steps
The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the addition of a...
01:36What is Gene Expression?
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then processed and...