Beyond working memory: the role of persistent activity in decision making
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Updated: Jun 14, 2026

An Automated T-maze Based Apparatus and Protocol for Analyzing Delay- and Effort-based Decision Making in Free Moving Rodents
Published on: August 2, 2018
Clayton E Curtis1, Daeyeol Lee
1Department of Psychology and Center for Neural Science, New York University, 6 Washington Place, New York, NY 10003, USA.
Abstract:
Since its first discovery in the prefrontal cortex, persistent activity during the interval between a transient sensory stimulus and a subsequent behavioral response has been identified in many cortical and subcortical areas. Such persistent activity is thought to reflect the maintenance of working memory representations that bridge past events with future contingent plans. Indeed, the term persistent activity is sometimes used interchangeably with working memory. In this review, we argue that persistent activity observed broadly across many cortical and subcortical areas reflects not only working memory maintenance, but also a variety of other cognitive processes, including perceptual and reward-based decision making.
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