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Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice
Published on: February 18, 2015
Host responses to Candida albicans: Th17 cells and mucosal candidiasis
Heather R Conti1, Sarah L Gaffen
1University at Buffalo, SUNY, Department of Oral Biology, Buffalo, NY, USA.
Abstract:
Candida albicans causes mucosal and disseminated candidiasis, which represent serious problems for the rapidly expanding immunocompromised population. Until recently, Th1-mediated immunity was thought to confer the primary protection, particularly for oral candidiasis. However, emerging data indicate that the newly-defined Th17 compartment appears to play the predominant role in mucosal candidiasis.
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