Related Experiment Video
Updated: Sep 10, 2026
08:02
Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice
Published on: February 18, 2015
Speedy delivery: EV-derived fungal antigens establish oral-gut Th17 crosstalk
Joanne E Konkel1, Sarah L Gaffen2
1Lydia Becker Institute of Immunology and Inflammation Research, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK; Medical Research Council Centre of Research Excellence in Exposome Immunology, University of Manchester, Manchester M13 9PL, UK.
Immunity
|September 8, 2026
Abstract:
Candida albicans induces Th17 cells, but their origins remain unresolved. In this issue of Immunity, Martini et al. show that the mouth is a reservoir for fungal Th17 cells that adopt pathogenic signatures in the gut during Crohn's disease.
