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Updated: Jun 14, 2026

Intravascular Delivery of Biologics to the Rat Kidney

Intravascular Delivery of Biologics to the Rat Kidney

Published on: September 1, 2016

Atheroembolic renal disease.

Francesco Scolari¹, Pietro Ravani

¹Faculty of Medicine, University of Brescia, Brescia, Italy. fscolar@tin.it

Lancet (London, England)

|April 13, 2010

Summary

This summary is machine-generated.

Atheroembolic renal disease, caused by cholesterol crystals blocking kidney arteries, has a poor prognosis. Prevention and symptomatic treatment, including statins, are key, with steroids potentially aiding severe cases.

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Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients

Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients

Published on: September 20, 2020

Area of Science:

Nephrology
Cardiovascular Medicine
Pathology

Background:

Atheroembolic renal disease results from atheromatous plaque rupture and cholesterol crystal embolization to renal arteries.
Embolization can affect multiple organs, including skin, gastrointestinal tract, and brain, complicating diagnosis.
The condition often arises after vascular procedures or anticoagulation, though spontaneous cases occur.

Purpose of the Study:

To summarize the pathophysiology, diagnosis, prognosis, and management of atheroembolic renal disease.
To highlight the diagnostic challenges and key clinical features.
To outline current and potential therapeutic strategies.

Main Methods:

Review of existing literature on atheroembolic renal disease.
Analysis of diagnostic criteria, including clinical presentation and supportive findings.
Evaluation of treatment modalities and prognostic factors.

Main Results:

The classic diagnostic triad includes a precipitating event, acute/subacute renal failure, and skin lesions.
Eosinophilia and cholesterol crystals in retinal circulation support the diagnosis, often confirmed by biopsy.
Prognosis for both renal function and patient survival is generally poor.

Conclusions:

Early recognition and avoidance of precipitating factors are crucial for prevention.
Symptomatic management of hypertension, cardiac, and renal failure is essential.
Statins are recommended for plaque stabilization; steroids may benefit inflammatory cases.