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Updated: Jun 13, 2026

Standards for Quantitative Metalloproteomic Analysis Using Size Exclusion ICP-MS
Published on: April 13, 2016
[Simultaneous correction for blood matrix effect on determination of magnesium, copper and lead concentration in
Le Yang1, Jing Zeng, Xiao-Yan Wang
1School of Public Health, Peking University, Beijing 100191, China. leyang.bj@gmail.com
Abstract:
The influence of matrix effect on the determination of magnesium, copper and lead in human blood matrix stimulant and its correction was studied by using both conventional internal reference method & common analyte internal standardization (CAIS). The obtained results indicate that CAIS method is applicable for simultaneous correction of multi-elements in blood matrix. The relative errors between the determined and the true values are 3.05% (by CAIS method), 12.39% (by conventional internal reference correction) and 23.91% (without correction), respectively. Otherwise, the influences of the mass discrepancy and that of the determination intensities between elements are not obvious for the correction of blood matrix. The reliability of CAIS was validated by the determination of both bovine blood and bovine serum standard materials.
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