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Updated: May 25, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
Association of ADRB1 gene polymorphism with atrial fibrillation
Svetlana Nicoulina1, Vladimir Shulman, Pavel Shesternya
1Krasnoyarsk State Medical University, Krasnoyarsk, Russia. nicoulina@mail.ru
Aim:
The purpose of this study was to establish the probability and patterns of atrial fibrillation (AF) inheritance in families, and to find an association of primary and secondary AF with polymorphism Ser49Gly of the gene encoding beta1-adrenoreceptor (ADRB1).
Methods:
We examined 103 probands with AF and 301 relatives. Physical examination, electrocardiography (ECG), echocardiography, Holter's monitoring of ECG, and other methods of functional diagnostics have been performed for all patients and their relatives. Genetic study has been performed using DNA extracted from peripheral blood leukocytes.
Results:
Our results show that probands with primary AF and their relatives have a prevalence of the heterozygous genotype (Ser49Gly) of ADRB1 gene compared with the control group: 15 (50.0%) probands and 11 (44.0%) relatives, respectively, and 38 (19.2%) in the control group (p < 0.05). Significant prevalence of heterozygous genotype (Ser49Gly) of ADRB1 gene was observed in patients of the second subgroup with secondary AF: 14 (46.7%) persons in comparison with 38 (19.2%) persons of the control group (p < 0.05).
Conclusion:
Heterozygous genotype (Ser49Gly) of ADRB1 gene can be considered as one of the genetic predictors for development of primary or secondary AF. Relatives of probands with primary AF and genotype Ser49Gly should be included in the risk group for developing AF.
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