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Perineural invasion: correlation with aggressive phenotype and independent prognostic variable in both colon and

Eva M Poeschl, Marion J Pollheimer, Peter Kornprat

    Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
    |April 14, 2010
    PubMed
    Abstract

    No abstract available in PubMed .

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    Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
    Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
    Tumor Progression02:07

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